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Biological Data
| Biological description | β-catenin inhibitor (Kd = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide |
| Chemical structure | ![PNU 74654 [113906-27-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "PNU 74654 [113906-27-7]") |
| Molecular Formula | C19H16N2O3 |
| PubChem identifier | 60119583 |
| SMILES | CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3 |
| InChiKey | JJEDWBQZCRESJL-DEDYPNTBSA-N |
References for PNU 74654
References are publications that support the biological activity of the product
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Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.
Durand J et al (2011) J Clin Endocrinol Metab 96(7) : E1206-11. -
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells JA et al (2007) Nature 450(7172) : 1001-9. -
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset JY et al (2006) Proteins 64(1) : 60-7.
β-catenin inhibitor. Wnt pathway inhibitor. Promotes neural differentiation of hPSCs.
![PNU 74654 [113906-27-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0528.png "PNU 74654 [113906-27-7]")
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