Product overview

Name PNU 74654
Description β-catenin inhibitor. Wnt pathway inhibitor. Promotes neural differentiation of hPSCs.
Purity >99%
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Biological Data

Biological description β-catenin inhibitor (Kd = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Molecular Weight 320.34
Chemical structure PNU 74654  [113906-27-7] Chemical Structure
Molecular Formula C19H16N2O3
CAS Number 113906-27-7
PubChem identifier 60119583
SMILES CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
InChiKey JJEDWBQZCRESJL-DEDYPNTBSA-N

References for PNU 74654

References are publications that support the biological activity of the product
  • Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

    Durand J et al (2011) J Clin Endocrinol Metab 96(7) : E1206-11.
  • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

    Wells JA et al (2007) Nature 450(7172) : 1001-9.
  • Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

    Trosset JY et al (2006) Proteins 64(1) : 60-7.