My Cart
My account
Menu
Main Menu

PNU 74654

(HB0528)
Be the first to add a publication
Technical documents: Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name PNU 74654
Purity >99%
Description β-catenin inhibitor. Wnt pathway inhibitor. Promotes neural differentiation of hPSCs.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
Write Your Own Review
You're reviewing:PNU 74654
Rate this item:

Biological Data

Biological description β-catenin inhibitor (Kd = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >99%
Chemical name 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Molecular Weight 320.34
Chemical structure PNU 74654 [113906-27-7] Chemical Structure
Molecular Formula C19H16N2O3
CAS Number 113906-27-7
PubChem identifier 60119583
SMILES CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
InChiKey JJEDWBQZCRESJL-DEDYPNTBSA-N

References for PNU 74654

References are publications that support the biological activity of the product

  • Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

    Durand J et al (2011) J Clin Endocrinol Metab 96(7) : E1206-11.
    Read more (PubMedID: 21565795)

  • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

    Wells JA et al (2007) Nature 450(7172) : 1001-9.
    Read more (PubMedID: 18075579)

  • Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

    Trosset JY et al (2006) Proteins 64(1) : 60-7.
    Read more (PubMedID: 16568448)

3 Item(s)

Grouped product items
Order: HB0528
Pack PriceQty
50mg
$591
β-catenin inhibitor. Wnt pathway inhibitor. Promotes neural differentiation of hPSCs.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com