Product overview

Name Ophiobolin A
Purity >95%
Description Irreversible calmodulin antagonist
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Biological Data

Biological description Irreversible calmodulin antagonist that reacts with lysine residues (IC50 0.87-3.7 µM). Also inhibits calcium-dependent human growth hormone (hGH) release (approx Ki = 10 µM). A membrane permeable fungal metabolite and a phytotoxin. Displays antitumor and apoptotic inducing properties.

Solubility & Handling

Solubility overview Soluble in DMSO or DMF
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name Cochliobolin A
Molecular Weight 400.6
Chemical structure Ophiobolin A  [988837] Chemical Structure
Molecular Formula C25H36O4
CAS Number 4611-05-6
PubChem identifier 5281387
SMILES C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C([C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C

References for Ophiobolin A

References are publications that support the biological activity of the product
  • Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.

    Bury M et al (2013) Int J Oncol 43(2) : 575-85.
  • Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.

    Quetglas S et al (2002) EMBO J 21(15) : 3970-9.
  • Identification of the binding and inhibition sites in the calmodulin molecule for ophiobolin A by site-directed mutagenesis.

    Kong Au T et al (1998) Plant Physiol 118(3) : 965-73.

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