Non-selective histone deacetylase (HDAC) inhibitor. Causes reactive oxygen species release and damages DNA. Shows anti-proliferative, apoptotic, anti-cancer and anti-protozoal actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) or ethanol (10mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent.
Strobl JS et al (2009) J Parasitol 95(1) : 215-23.
Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.
Martirosyan A et al (2006) J Pharmacol Exp Ther 317(2) : 546-52.
![NSC 3852 [3565-26-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1392.png "NSC 3852 [3565-26-2]")
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