Product overview

Name NSC 3852
Alternative names 5-nitroso-8-quinolinol
Description Non-selective HDAC inhibitor
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Biological Data

Biological description Non-selective histone deacetylase (HDAC) inhibitor. Causes reactive oxygen species release and damages DNA. Shows anti-proliferative, apoptotic, anti-cancer and anti-protozoal actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 5-Nitroso-8-quinolinol
Molecular Weight 174.16
Chemical structure NSC 3852  [3565-26-2] Chemical Structure
Molecular Formula C9H6N2O2
CAS Number 3565-26-2
PubChem identifier 19103

References for NSC 3852

References are publications that support the biological activity of the product
  • Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent.

    Strobl JS et al (2009) J Parasitol 95(1) : 215-23.
  • Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.

    Martirosyan A et al (2006) J Pharmacol Exp Ther 317(2) : 546-52.
  • Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model.

    Martirosyan AR et al (2004) Biochem Pharmacol 68(9) : 1729-38.

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