The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Potent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (5mM, gentle warming) or ethanol (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol |
| Chemical structure | ![NSC 33994 [82058-16-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "NSC 33994 [82058-16-0]") |
| Molecular Formula | C28H42N2O2 |
| PubChem identifier | 5473838 |
| SMILES | CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1 |
| InChiKey | QFNJFVBKASKGEU-OCEACIFDSA-N |
References for NSC 33994
References are publications that support the biological activity of the product
-
The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.
Baskin R et al (2014) PLoS One 9(8) : e105568. -
The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Kirabo A et al (2011) Neoplasia 13(11) : 1058-68. -
Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
Kiss R et al (2009) Bioorg Med Chem Lett 19(13) : 3598-601.
Potent, selective JAK2 inhibitor
![NSC 33994 [82058-16-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1430.png "NSC 33994 [82058-16-0]")
Understanding purity and quality - a guide for life scientists