Product overview

Name Methylene Blue
Biological description Biological dye, redox indicator and soluble guanylyl cyclase inhibitor. Reduces tau protein aggregation (IC50 = 1.9 µM). Also shows antimalarial, antioxidant and neuroprotective actions.
Purity >80%
Description Biological dye, redox indicator and soluble guanylyl cyclase inhibitor
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Methylene Blue product vial image | Hello Bio

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (50mg/ml), and in ethanol (70mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >80%
Chemical name [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium chloride
Molecular Weight 373.9
Chemical structure Methylene Blue  [7220-79-3] Chemical Structure
Molecular Formula C16H18ClN3S
CAS Number 7220-79-3
PubChem identifier 104827
SMILES CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.O.O.O.[Cl-]
InChiKey XQAXGZLFSSPBMK-UHFFFAOYSA-M
MDL number MFCD00150006
Appearance Green solid

References for Methylene Blue

References are publications that support the biological activity of the product
  • Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model.

    Dormoi J et al (2013) Antimicrob Agents Chemother 57(7) : 3412-4.
  • Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.

    Hosokawa M et al (2012) PLoS One 7(12) : e52389.
  • Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

    Taniguchi S et al (2005) J Biol Chem 280(9) : 7614-23.
  • Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.

    Hwang TL et al (1998) Br J Pharmacol 125(6) : 1158-63.

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