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Methylene Blue

(HB0409)
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Product overview

Name Methylene Blue
Biological description Biological dye, redox indicator and soluble guanylyl cyclase inhibitor. Reduces tau protein aggregation (IC50 = 1.9 µM). Also shows antimalarial, antioxidant and neuroprotective actions.
Purity >80%
Description Biological dye, redox indicator and soluble guanylyl cyclase inhibitor
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Images

Methylene Blue product vial image | Hello Bio
Methylene Blue product vial image | Hello Bio

Methylene Blue product vial image | Hello Bio

Methylene Blue product vial image | Hello Bio

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (50mg/ml), and in ethanol (70mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >80%
Chemical name [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium chloride
Molecular Weight 373.9
Chemical structure Methylene Blue [7220-79-3] Chemical Structure
Molecular Formula C16H18ClN3S
CAS Number 7220-79-3
PubChem identifier 104827
SMILES CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.O.O.O.[Cl-]
InChiKey XQAXGZLFSSPBMK-UHFFFAOYSA-M
MDL number MFCD00150006
Appearance Green solid

References for Methylene Blue

References are publications that support the biological activity of the product

  • Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model.

    Dormoi J et al (2013) Antimicrob Agents Chemother 57(7) : 3412-4.
    Read more (PubMedID: 23612202)

  • Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.

    Hosokawa M et al (2012) PLoS One 7(12) : e52389.
    Read more (PubMedID: 23285020)

  • Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

    Taniguchi S et al (2005) J Biol Chem 280(9) : 7614-23.
    Read more (PubMedID: 15611092)

  • Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.

    Hwang TL et al (1998) Br J Pharmacol 125(6) : 1158-63.
    Read more (PubMedID: 9863642)

4 Item(s)

Related Products
Grouped product items
Order: HB0409
Pack PriceQty
50mg
$58
1g
$134
Biological dye, redox indicator and soluble guanylyl cyclase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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