Cx36 and Cx50 gap channel blocker (IC50 values are 0.3 and 1.1 µM, respectively). Other gap junctions (e.g. Cx43, Cx32, and Cx26) are only affected at concentrations 10-100 fold higher. In neocortical slices, mefloquine blocks gap junctional coupling between interneurons with minimal nonspecific actions.
Also shows antimalarial action. Inhibits the 80S ribosome of Plasmodium falciparum to block protein synthesis.
Additionally shows antischistosomal and antiviral actions and has recently been investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Solubility overview
Soluble in DMSO (50 mM), and in ethanol (100 mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
![Mefloquine hydrochloride [51773-92-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb9555_1.png "Mefloquine hydrochloride [51773-92-3]")
