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MC 1568

(HB1390)
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Product overview

Name MC 1568
Purity >96%
Description Selective class IIa HDAC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective class IIa histone deacetylase (HDAC) inhibitor. Inhibits HDAC4 and HDAC5 in the heart and skeletal muscle and suppresses myogenesis. Also inhibits IL-8 expression and promotes neurite growth. Shows neuroprotective, anti-proliferative and anti-cancer actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >96%
Chemical name 3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
Molecular Weight 314.31
Chemical structure MC 1568 [852475-26-4] Chemical Structure
Molecular Formula C17H15FN2O3
CAS Number 852475-26-4
PubChem identifier 11381449
SMILES CN1C=C(/C=C/C(C2=CC(F)=CC=C2)=O)C=C1/C=C/C(NO)=O
InChiKey QRDAPCMJAOQZSU-KQQUZDAGSA-N

References for MC 1568

References are publications that support the biological activity of the product

  • Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

    Collins LM et al (2014) Mol Neurobiol :
    Read more (PubMedID: 25065734)

  • Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.

    Venza I et al (2013) Pigment Cell Melanoma Res 26(2) : 193-204.
    Read more (PubMedID: 23176534)

  • Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

    Nebbioso A et al (2009) EMBO Rep 10(7) : 776-82.
    Read more (PubMedID: 19498465)

3 Item(s)

Grouped product items
Order: HB1390
Pack PriceQty
25mg
$580
Selective class IIa HDAC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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