Product overview

Name MC 1568
Purity >96%
Description Selective class IIa HDAC inhibitor
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Biological Data

Biological description Selective class IIa histone deacetylase (HDAC) inhibitor. Inhibits HDAC4 and HDAC5 in the heart and skeletal muscle and suppresses myogenesis. Also inhibits IL-8 expression and promotes neurite growth. Shows neuroprotective, anti-proliferative and anti-cancer actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >96%
Chemical name 3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
Molecular Weight 314.31
Chemical structure MC 1568  [852475-26-4] Chemical Structure
Molecular Formula C17H15FN2O3
CAS Number 852475-26-4
PubChem identifier 11381449

References for MC 1568

References are publications that support the biological activity of the product
  • Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

    Collins LM et al (2014) Mol Neurobiol :
  • Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.

    Venza I et al (2013) Pigment Cell Melanoma Res 26(2) : 193-204.
  • Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

    Nebbioso A et al (2009) EMBO Rep 10(7) : 776-82.

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