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IRL-1620

(HB3411)
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Technical documents: SDS CoA Datasheet
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Product overview

Name IRL-1620
Biological description

Overview

IRL-1620 is a synthetic analog of endothelin-1. It is a highly selective ETB receptor agonist (Ki values are 16 pM and 1.9 µM at ETB and ETA receptors respectively).

IRL1620 is ~60 times more selective for the ETB receptor than Endothelin-3.

Uses & applications

IRL-1620 causes vasodilation by inducing nitric oxide (NO) release and has been shown to increase effectiveness of paclitaxel in breast cancer animal models. It may also have neuroprotective effects.

Purity >95%
Description Highly selective ETB agonist
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (0.5 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >95%
Chemical name DEEAVYFAHLDIIW (Asp-1 = Suc-Asp)
Molecular Weight 1820.97
Chemical structure IRL-1620 [142569-99-1] Chemical Structure
Molecular Formula C86H117N17O27
Sequence (one letter) DEEAVYFAHLDIIW
Sequence (three letter) Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Modifications Asp-1 = Suc-Asp
CAS Number 142569-99-1 
PubChem identifier 16133819
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O
InChiKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Protein length 14

References for IRL-1620

References are publications that support the biological activity of the product

  • Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion

    Cifuentes EG et al (2018) Front Pediatr 6 : 310
    Read more (PubMedID: 30406063)

  • Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease

    Briyal S et al (2015) Neuroscience 301 : 01-11
    Read more (PubMedID: 26022359)

  • Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats

    Rajeshkumar NV et al (2005) Breast Cancer Res Treat 94(3) : 237-47
    Read more (PubMedID: 16244791)

  • A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor

    Takai M et al (1992) Biochem Biophys Res Commun 184(2) : 953-9
    Read more (PubMedID: 1315540)

4 Item(s)

Related Products
Grouped product items
Order: HB3411
Pack PriceQty
500μg
$158
Highly selective ETB agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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