Ibrutinib

(HB4204)
Technical documents: Datasheet
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Product overview

Name Ibrutinib
Purity >98%
Description Potent, selective Bruton's tyrosine kinase (BTK) inhibitor.
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Biological Data

Biological description Potent and selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 440.5
Chemical structure Ibrutinib [936563-96-1] Chemical Structure
CAS Number 936563-96-1
Appearance White solid