Hello Bio launches novel water-soluble high potency DREADD ligands, licensed from the NIH

03 Sep 2018

Hello Bio announced today the launch of novel water-soluble and highly potent hM3Dq & hM4Di ligands – exciting tools for scientists studying GPCR and DREADD signalling. Hello Bio has been granted a licence from the National Institute of Health Office of Technology Transfer to manufacture these novel tools and make them commercially available to life scientists worldwide for the first time.

JHU37160 dihydrochloride and JHU37152 dihydrochloride are novel DREADD ligands with higher potency at hM3Dq and hM4Di DREADDs in in vitro functional assays than the commonly used clozapine N-oxide (CNO) or the more recent DREADD agonist 21 (Compound 21).
Both JHU37160 and JHU37152 have high affinity for hM4Di and hM3Dq. They are active in vivo, following ip administration, and are available from Hello Bio as both the water-soluble dihydrochloride salts, and freebase forms. They are sold under licence from the NIH (US Patent Pending 62/627,527), and Hello Bio are the first life science supplier to offer these products to the research community.

We are delighted to have been granted a licence from the National Institutes of Health to make these novel DREADDs ligands JHU37160 and JHU37152 available to the scientific research community. Our chemists have used their expertise in DREADDs to manufacture these products at high purity (>98%), in water-soluble and freebase forms, enabling researchers to use them with confidence in their experiments.

These new tools join Hello Bio’s unique range of DREADD ligands which includes clozapine N-oxide dihydrochloride (water soluble), DREADD agonist 21 (Compound 21) dihydrochloride (water-soluble) and perlapine dihydrochloride (water-soluble). We hope that JHU37160 and JHU37152 will contribute to further pushing this exciting field of research forwards.

Steve Roome PhD, Managing Director and Founder, Hello Bio



For more information, please contact 
Steve Roome:
(0)117 3180 505


About Hello Bio

Hello Bio was founded by a team of experienced scientists and chemists who genuinely want to support life science research. Our aim is to offer a range of high quality life science tools at prices so low that as many researchers as possible will be able to afford them.
They offer a range of agonists, antagonists, inhibitors, activators, antibodies and fluorescent tools at up to half the price of other suppliers. The range includes: receptor ligands, enzyme inhibitors and activators, ion channel modulators, epigenetic tools, signalling tools and stem cell modulators. Hello Bio also provides a cost effective custom synthesis service for customers requiring specialist tools, or bulk quantities.

About the NIH Office of Technology Transfer (NIH-OTT)

NIH-OTT manages the patenting and licensing of a wide range of inventions made by scientists working for the NIH and FDA intramural research programs as mandated by the Federal Technology Transfer Act.
Additional information about NIH-OTT can be found at http://www.ott.nih.gov.


GPCRs can be modified so that they only respond to a specific biologically inert chemical (a designer drug). These modified GPCRs are called Designer Receptors Exclusively Activated by Designer Drugs or “DREADDs”. Cells expressing the DREADD respond robustly to low concentrations of the designer molecule, whereas cells that do not express DREADD are unresponsive to the designer drug. DREADDs are functionally similar to their wild type receptors, therefore they are useful tools for the study of GPCR signaling. Ligands for these receptors include: clozapine N-oxide dihydrochloride (water soluble), DREADD agonist 21 (Compound 21) dihydrochloride (water-soluble) and perlapine dihydrochloride (water-soluble). For more information see the DREADDs mini-review.