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FK 228

(HB1386)
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Product overview

Name FK 228
Alternative names Romidepsin; depsipeptide
Purity >98%
Description Potent, selective HDAC1 / HDAC2 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective histone deacetylase (HDAC) inhibitor. Selective for class I HDAC1 and HDAC2 over class II HDAC4 and HDAC6 (IC50 values are 36, 47, 510 nM and 14 µM respectively). Induces human fetal hemoglobin. Shows growth inhibitory, apoptotic and anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name Cyclo[(2Z)-2-amino-2-butenoyl-L-val yl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valy l-D-cysteinyl], cyclic (3-5) disulfide
Molecular Weight 540.7
Chemical structure FK 228 [128517-07-7] Chemical Structure
Molecular Formula C24H36N4O6S2
CAS Number 128517-07-7
PubChem identifier 5352062
SMILES O=C([C@H]([C@H](C)C)NC(/C(NC([C@@H]2NC([C@@H]([C@H](C)C)N1)=O)=O)=C/C)=O)O[C@H](/C=C/CCSSC2)CC1=O
InChiKey OHRURASPPZQGQM-GCCNXGTGSA-N

References for FK 228

References are publications that support the biological activity of the product

  • Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

    Cao H et al (2006) Am J Hematol 81(12) : 981-3.
    Read more (PubMedID: 16888791)

  • FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

    Furumai R et al (2002) Cancer Res 62(17) : 4916-21.
    Read more (PubMedID: 12208741)

  • Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo.

    Sasakawa Y et al (2002) Biochem Pharmacol 64(7) : 1079-90.
    Read more (PubMedID: 12234611)

3 Item(s)

Grouped product items
Order: HB1386
Pack PriceQty
5mg
$1,074
Potent, selective HDAC1 / HDAC2 inhibitor
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