Product overview

Name FK 228
Alternative names Romidepsin; depsipeptide
Purity >98%
Description Potent, selective HDAC1 / HDAC2 inhibitor
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Biological Data

Biological description Potent and selective histone deacetylase (HDAC) inhibitor. Selective for class I HDAC1 and HDAC2 over class II HDAC4 and HDAC6 (IC50 values are 36, 47, 510 nM and 14 µM respectively). Induces human fetal hemoglobin. Shows growth inhibitory, apoptotic and anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name Cyclo[(2Z)-2-amino-2-butenoyl-L-val yl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valy l-D-cysteinyl], cyclic (3-5) disulfide
Molecular Weight 540.7
Chemical structure FK 228  [128517-07-7] Chemical Structure
Molecular Formula C24H36N4O6S2
CAS Number 128517-07-7
PubChem identifier 5352062
SMILES O=C([C@H]([C@H](C)C)NC(/C(NC([C@@H]2NC([C@@H]([C@H](C)C)N1)=O)=O)=C/C)=O)O[C@H](/C=C/CCSSC2)CC1=O

References for FK 228

References are publications that support the biological activity of the product
  • Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

    Cao H et al (2006) Am J Hematol 81(12) : 981-3.
  • FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

    Furumai R et al (2002) Cancer Res 62(17) : 4916-21.
  • Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo.

    Sasakawa Y et al (2002) Biochem Pharmacol 64(7) : 1079-90.

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