FCH-2996413 sodium (Peripherally restricted HCAD DREADD actuator) [Water Soluble]

Novel DREADD actuator for the first peripherally restricted DREADD system named the HCAD DREADD system. Water soluble. The HCAD system enables precise study of peripheral physiology without CNS interference.

FCH-2996413 does not cross the BBB (unlike other DREADD ligands (e.g. CNO & DCZ)), so can selectively activate the novel, peripherally restricted HCAD G_i-DREADD. Few DREADD studies have been conducted in the PNS to date.

FCH-2996413 has excellent drug-like properties, peripherally restricted pharmacokinetics and clean off-target profiles. The HCAD system also selectively reduces pain in mice by targeting peripheral tissues of DRG (dorsal root ganglion). Active in vivo. FCH-2996413 is a racemic mixture which includes the racemates AR2599088 ('088) and AR259089 ('089).