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Daphnetin

(HB0229)
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Technical documents: CoA Datasheet
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Product overview

Name Daphnetin
Purity >97%
Description Protein kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Daphnetin product vial image | Hello Bio
Daphnetin product vial image | Hello Bio

Daphnetin product vial image | Hello Bio

Daphnetin product vial image | Hello Bio

Biological Data

Biological description Protein kinase inhibitor (IC50 values are 7.67, 9.33 and 25.01 µM at EGFR, PKA and PKC respectively). Cell-permeable, coumarin derivative. Shows antioxidant and antimalarial actions.

Solubility & Handling

Solubility overview Soluble in DMSO or EtOH
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >97%
Chemical name 7,8-Dihydroxycoumarin
Molecular Weight 178.14
Chemical structure Daphnetin [486-35-1] Chemical Structure
Molecular Formula C9H6O4
CAS Number 486-35-1
PubChem identifier 5280569
SMILES C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChi InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChiKey ATEFPOUAMCWAQS-UHFFFAOYSA-N
MDL number MFCD00016977

References for Daphnetin

References are publications that support the biological activity of the product

  • Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury.

    Du G et al (2014) Neurochem Res 39(2) : 269-75.
    Read more (PubMedID: 24343531)

  • Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.

    Yang EB et al (1999) Biochem Biophys Res Commun 260(3) : 682-5.
    Read more (PubMedID: 10403826)

  • Daphnetin: a novel antimalarial agent with in vitro and in vivo activity.

    Yang YZ et al (1992) Am J Trop Med Hyg 46(1) : 15-20.
    Read more (PubMedID: 1311154)

3 Item(s)

Grouped product items
Order: HB0229
Pack PriceQty
5mg
$80
25mg
$320
10mg
$76
Protein kinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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