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Biological Data
| Biological description | Potent and selective histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 6 and 8 (IC50 values are 0.41, 0.75, >100 and >100 µM respectively). Induces histone H3 hyperacetylation and cell differentiation. Shows anti-proliferative and apoptotic actions. Cell-permeable. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 4-(Acetylamino)-N-(2-aminophenyl)be nzamide |
| Chemical structure | ![CI 994 [112522-64-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CI 994 [112522-64-2]") |
| Molecular Formula | C15H15N3O2 |
| SMILES | O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1 |
| InChiKey | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
References for CI 994
References are publications that support the biological activity of the product
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Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Beckers T et al (2007) Int J Cancer 121(5) : 1138-48. -
In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines.
Loprevite M et al (2005) Oncol Res 15(1) : 39-48. -
Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma.
Kraker AJ et al (2003) Mol Cancer Ther 2(4) : 401-8.
Potent, selective HDAC inhibitor
![CI 994 [112522-64-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1385.png "CI 994 [112522-64-2]")
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