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Chelerythrine Chloride

(HB0190)
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Product overview

Name Chelerythrine Chloride
Alternative names CHE
Purity >98%
Description PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3) Frequently bought together
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Chelerythrine Chloride product vial image | Hello Bio
Chelerythrine Chloride product vial image | Hello Bio

Chelerythrine Chloride product vial image | Hello Bio

Chelerythrine Chloride product vial image | Hello Bio

Biological Data

Biological description Protein kinase C (PKC) inhibitor (IC50 = 660 nM). Competitive inhibitor of the phosphate acceptor, non-competitive ATP inhibitor. Inhibits BclXL function; inhibits BclXL-Bak BH3 peptide binding (IC50 = 1.5 μM). Shows apoptotic and antitumor actions.

Solubility & Handling

Solubility overview Soluble in water (10mM) or DMSO (10mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Molecular Weight 383.83
Chemical structure Chelerythrine Chloride [3895-92-9] Chemical Structure
Molecular Formula C21H18ClNO4
CAS Number 3895-92-9
PubChem identifier 72311
SMILES C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.Cl
InChiKey WEEFNMFMNMASJY-UHFFFAOYSA-M

References for Chelerythrine Chloride

References are publications that support the biological activity of the product

  • Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.

    Zhang ZF et al (2011) Arch Pharm Res 34(5) : 791-800.
    Read more (PubMedID: 21656365)

  • Identification of chelerythrine as an inhibitor of BclXL function.

    Chan SL et al (2003) J Biol Chem 278(23) : 20453-6.
    Read more (PubMedID: 12702731)

  • Chelerythrine is a potent and specific inhibitor of protein kinase C.

    Herbert JM et al (1990) Biochem Biophys Res Commun 172(3) : 993-9.
    Read more (PubMedID: 2244923)

3 Item(s)

Grouped product items
Order: HB0190
Pack PriceQty
5mg
$128
25mg
$446
PKC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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