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Images
Chelerythrine Chloride product vial image | Hello Bio
Chelerythrine Chloride product vial image | Hello Bio
Biological Data
| Biological description | Protein kinase C (PKC) inhibitor (IC50 = 660 nM). Competitive inhibitor of the phosphate acceptor, non-competitive ATP inhibitor. Inhibits BclXL function; inhibits BclXL-Bak BH3 peptide binding (IC50 = 1.5 μM). Shows apoptotic and antitumor actions. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (10mM) or DMSO (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
| Chemical structure | ![Chelerythrine Chloride [3895-92-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Chelerythrine Chloride [3895-92-9]") |
| Molecular Formula | C21H18ClNO4 |
| SMILES | C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.Cl |
| InChiKey | WEEFNMFMNMASJY-UHFFFAOYSA-M |
References for Chelerythrine Chloride
References are publications that support the biological activity of the product
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Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.
Zhang ZF et al (2011) Arch Pharm Res 34(5) : 791-800. -
Identification of chelerythrine as an inhibitor of BclXL function.
Chan SL et al (2003) J Biol Chem 278(23) : 20453-6. -
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Herbert JM et al (1990) Biochem Biophys Res Commun 172(3) : 993-9.
![Chelerythrine Chloride [3895-92-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0190.png "Chelerythrine Chloride [3895-92-9]")
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