Product overview

Name Chelerythrine Chloride
Alternative names CHE
Purity >98%
Description PKC inhibitor
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Biological Data

Biological description Protein kinase C (PKC) inhibitor (IC50 = 660 nM). Competitive inhibitor of the phosphate acceptor, non-competitive ATP inhibitor. Inhibits BclXL function; inhibits BclXL-Bak BH3 peptide binding (IC50 = 1.5 μM). Shows apoptotic and antitumor actions.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (10mM) or DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Molecular Weight 383.83
Chemical structure Chelerythrine Chloride  [3895-92-9] Chemical Structure
Molecular Formula C21H18ClNO4
CAS Number 3895-92-9
PubChem identifier 72311
SMILES C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.Cl

References for Chelerythrine Chloride

References are publications that support the biological activity of the product
  • Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.

    Zhang ZF et al (2011) Arch Pharm Res 34(5) : 791-800.
  • Identification of chelerythrine as an inhibitor of BclXL function.

    Chan SL et al (2003) J Biol Chem 278(23) : 20453-6.
  • Chelerythrine is a potent and specific inhibitor of protein kinase C.

    Herbert JM et al (1990) Biochem Biophys Res Commun 172(3) : 993-9.

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