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Fluorescent GABAB antagonist (pKD = 7.97). A fluorescent GABAB receptor ligand derived from CGP-54626A GABAB antagonist. Shown to antagonize the activity of the GABA.
For imaging at the GABAB1/B2 receptor use solutions up to 100 nM.
Pharmacological validation
The CA200931 Fluorescent GABAB receptor antagonist was shown to antagonize the activity of the GABAB agonist, GABA, in a recombinant CHO cell line expressing the human GABAB1 and GABAB2 receptors and a serum-responsive secreted placental alkaline phosphatase (SPAP) reporter gene. The serum-induced expression of SPAP was measured under basal and serum-stimulated (maximal) conditions. Addition of CA200931 to the basal or serum-stimulated cells did not significantly alter basal and stimulated SPAP levels, demonstrating that the CA200931 fluorescent GABAB receptor antagonist has no intrinsic agonist activity.
Solubility & Handling
Storage instructions
-20°C (protect from light)
Solubility overview
Soluble in DMSO
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Handling
After thawing individual aliquots for use, we recommend briefly sonicating the sample to ensure it is fully dissolved and the solution is homogeneous. We do not recommend using the product after subjecting it to repetitive freeze-thaw cycles.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
CellAura Fluorescent Ligands technical FAQs (274.2 KB) 
