Product overview

Name Calmidazolium Chloride
Description Calmodulin (CaM) antagonist
Alternative names R 24571
Purity >98%
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Biological Data

Biological description Calmodulin (CaM) antagonist. Inhibits calmodulin-dependent phosphodiesterase (IC50 = 0.15 µM). Antagonises Ca2+-transporting ATPase calmodulin-induced activation (IC50 = 0.35 µM). Inhibits adenylyl cyclase, soluble fusion protein, ACIX and ACV-ACII fusion proteins. Blocks L-type calcium channels as well as voltage-dependent Na+ and K+ channel currents; increases intracellular calcium. Shows cytotoxic and apoptotic effects.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-[Bis(4-chlorophenyl)methyl]-3-[2- (2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
Molecular Weight 687.7
Chemical structure Calmidazolium Chloride  [57265-65-3] Chemical Structure
Molecular Formula C31H23Cl7N2O
CAS Number 57265-65-3
PubChem identifier 644274
SMILES C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-]
InChiKey YGEIMSMISRCBFF-UHFFFAOYSA-M

References for Calmidazolium Chloride

References are publications that support the biological activity of the product
  • Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis.

    Kumar S et al (2009) Free Radic Biol Med 47(6) : 699-709.
  • Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium.

    Haunsø A et al (2003) Mol Pharmacol 63(3) : 624-31.
  • Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.

    Gietzen K (1983) Biochem J 216(3) : 611-6.