Product overview
| Name | AG 490 |
| Description | Selective EGF receptor tyrosine kinase inhibitor |
| Alternative names | Tyrphostin AG 490 |
| Purity | >99% |
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Biological Data
| Biological description | Selective EGF receptor tyrosine kinase inhibitor. Inhibits EGFR and ErbB2 (IC50 values are 2 and 13.5 µM respectively). Inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK signaling pathways. Inhibits IL-2-induced T cell proliferation. Shows anti-cancer actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (20mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N -(phenylmethyl)-2-propenamide |
| Molecular Weight | 294.31 |
| Chemical structure | ![AG 490 [133550-30-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1424.png "AG 490 [133550-30-8]") |
| Molecular Formula | C17H14N2O3 |
| CAS Number | 133550-30-8 |
| PubChem identifier | 5328779 |
| SMILES | OC1=C(O)C=C(\C=C(/C#N)C(=O)NCC2=CC=CC=C2)C=C1 |
| InChiKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
References for AG 490
References are publications that support the biological activity of the product
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
Wang LH et al (1999) J Immunol 162(7) : 3897-904. -
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.
Meydan N et al (1996) Nature 379(6566) : 645-8. -
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit A et al (1991) J Med Chem 34(6) : 1896-907.
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