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Biological Data Biological description Selective EGF receptor tyrosine kinase inhibitor. Inhibits EGFR and ErbB2 (IC50 values are 2 and 13.5 µM respectively). Inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK signaling pathways. Inhibits IL-2-induced T cell proliferation. Shows anti-cancer actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) or ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (E )-2-Cyano-3-(3,4-dihydrophenyl)-N -(phenylmethyl)-2-propenamide
Chemical structure
Molecular Formula C17 H14 N2 O3
PubChem identifier 5328779
SMILES OC1=C(O)C=C(\C=C(/C#N)C(=O)NCC2=CC=CC=C2)C=C1
InChiKey TUCIOBMMDDOEMM-RIYZIHGNSA-N
References for AG 490 References are publications that support the biological activity of the product
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. Wang LH et al (1999) J Immunol 162(7) : 3897-904. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Meydan N et al (1996) Nature 379(6566) : 645-8. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. Gazit A et al (1991) J Med Chem 34(6) : 1896-907.
Selective EGF receptor tyrosine kinase inhibitor
![AG 490 [133550-30-8] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1424.png "AG 490 [133550-30-8]")
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