Selective EGF receptor tyrosine kinase inhibitor. Inhibits EGFR and ErbB2 (IC50 values are 2 and 13.5 µM respectively). Inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK signaling pathways. Inhibits IL-2-induced T cell proliferation. Shows anti-cancer actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) or ethanol (20mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
![AG 490 [133550-30-8] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1424.png "AG 490 [133550-30-8]")
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