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7-Chlorokynurenic acid: Scientist Approved
7-Chlorokynurenic acid: Scientist Approved
Biological Data
| Biological description | Selective NMDA receptor antagonist (IC50 = 0.56 µM). Binds at the glycine site. Centrally acting with antidepressant and anticonvulsant activity. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) or NaOH (100mM, 1eq. NaOH) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 7-Chloro-4-hydroxyquinoline-2-carboxylic acid |
| Chemical structure | ![7-Chlorokynurenic acid [18000-24-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "7-Chlorokynurenic acid [18000-24-3]") |
| Molecular Formula | C10H6ClNO3 |
| SMILES | O=C(O)c1cc(O)c2ccc(Cl)cc2n1 |
| InChi | InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15) |
| InChiKey | UAWVRVFHMOSAPU-UHFFFAOYSA-N |
References for 7-Chlorokynurenic acid
References are publications that support the biological activity of the product
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Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.
Battaglia G et al (2000) Brain Res 860(1-2) : 149-56. -
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
Bonina FP et al (2000) Int J Pharm 202(1-2) : 79-88. -
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Kemp JA et al (1988) Proc Natl Acad Sci U S A 85(17) : 6547-50.
Publications
These publications cite the use of 7-Chlorokynurenic acid purchased from Hello Bio:
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Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Yi et al (2016) Neuron 91(6) : 1316-29
Selective NMDA receptor antagonist
![7-Chlorokynurenic acid [18000-24-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0086.png "7-Chlorokynurenic acid [18000-24-3]")
Understanding purity and quality - a guide for life scientists