7-Chlorokynurenic acid

(HB0086)
Technical documents: SDS Datasheet
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Product overview

Name 7-Chlorokynurenic acid
Alternative names 7-CKA
Purity >95%
Description Selective NMDA receptor antagonist
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7-Chlorokynurenic acid: Scientist Approved

Biological Data

Biological description Selective NMDA receptor antagonist (IC50 = 0.56 µM). Binds at the glycine site. Centrally acting with antidepressant and anticonvulsant activity.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) or NaOH (100mM, 1eq. NaOH)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Molecular Weight 223.62
Chemical structure 7-Chlorokynurenic acid  [18000-24-3] Chemical Structure
Molecular Formula C10H6ClNO3
CAS Number 18000-24-3
PubChem identifier 1884
SMILES O=C(O)c1cc(O)c2ccc(Cl)cc2n1
InChi InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
InChiKey UAWVRVFHMOSAPU-UHFFFAOYSA-N
MDL number MFCD00069227

References for 7-Chlorokynurenic acid

References are publications that support the biological activity of the product
  • Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.

    Battaglia G et al (2000) Brain Res 860(1-2) : 149-56.
  • Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.

    Bonina FP et al (2000) Int J Pharm 202(1-2) : 79-88.
  • 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

    Kemp JA et al (1988) Proc Natl Acad Sci U S A 85(17) : 6547-50.

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Publications
These publications cite the use of 7-Chlorokynurenic acid purchased from Hello Bio:
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

1 Item