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Biological Data
| Biological description | Irreversible caspase 2 inhibitor. Significantly reduces cell detachment, caspase-2 and -3 activity, DNA ladders, and proteolytic cleavage of PARP. Displays inhibitory apoptotic actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (13.791mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone |
| Molecular Formula | C32H46FN5O11 |
| SMILES | [H]N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1 |
References for Z-VDVAD-FMK
References are publications that support the biological activity of the product
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Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.
Chauvier D et al (2005) Apoptosis 10(6) : 1243-59. -
Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.
Meguro T et al (2001) Stroke 32(2) : 561-6. -
Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells.
Gamen S et al (2000) Exp Cell Res 258(1) : 223-35.
Irreversible caspase 2 inhibitor
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