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Z-VDVAD-FMK

(HB1286)
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Product overview

Name Z-VDVAD-FMK
Description Irreversible caspase 2 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Irreversible caspase 2 inhibitor. Significantly reduces cell detachment, caspase-2 and -3 activity, DNA ladders, and proteolytic cleavage of PARP. Displays inhibitory apoptotic actions.

Solubility & Handling

Solubility overview Soluble in DMSO (13.791mg/ml)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight 695.74
Molecular Formula C32H46FN5O11
SMILES [H]N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

References for Z-VDVAD-FMK

References are publications that support the biological activity of the product

  • Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.

    Chauvier D et al (2005) Apoptosis 10(6) : 1243-59.
    Read more (PubMedID: 16215683)

  • Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.

    Meguro T et al (2001) Stroke 32(2) : 561-6.
    Read more (PubMedID: 11157197)

  • Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells.

    Gamen S et al (2000) Exp Cell Res 258(1) : 223-35.
    Read more (PubMedID: 10912804)

3 Item(s)

Grouped product items
Order: HB1286
Pack PriceQty
1mg
$308
5mg
$1,224
Irreversible caspase 2 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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