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Wiskostatin

(HB0658)
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Product overview

Name Wiskostatin
Purity >99%
Description Potent, selective N-WASP inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor that interacts with GTPase- binding domain. Inhibits Arp2/3 complex activation. Decreases cellular ATP levels and inhibits cytokinesis but not mitosis. A carbazole derivative.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 3,6-Dibromo-α-[(dimethylamino)methyl ]-9H-cabazole-9-ethanol
Molecular Weight 426.15
Chemical structure Wiskostatin [253449-04-6] Chemical Structure
Molecular Formula C17H18Br2N2O
CAS Number 253449-04-6
PubChem identifier 2775510
SMILES BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2
InChiKey XUBJEDZHBUPBKL-UHFFFAOYSA-N

References for Wiskostatin

References are publications that support the biological activity of the product

  • Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway.

    Bompard G et al (2008) BMC Cell Biol 9 : 42
    Read more (PubMedID: 18667055)

  • N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.

    Guerriero CJ et al (2007) Am J Physiol Cell Physiol 292(4) : C1562-6.
    Read more (PubMedID: 17092993)

  • Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

    Peterson JR et al (2004) Nat Struct Mol Biol 11(8) : 747-55.
    Read more (PubMedID: 15235593)

3 Item(s)

Grouped product items
Order: HB0658
Pack PriceQty
50mg
$842
Potent, selective N-WASP inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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