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UNC 0646

(HB1423)
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Product overview

Name UNC 0646
Alternative names Compound 6
Purity >99%
Description Potent, selective G9a / GLP HMTase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2)
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Biological Data

Biological description Potent and selective G9a and G9a-like protein (GLP) histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 6 and < 15 nM respectively). Selective for G9a and GLP over other methyltransferases.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6 -methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolin amine
Molecular Weight 621.9
Chemical structure UNC 0646 [1320288-17-2] Chemical Structure
Molecular Formula C36H59N7O2
CAS Number 1320288-17-2
PubChem identifier 53315882
SMILES CC(C)N(CC6)CCCN6C1=NC(NC3CCN(C5CCCCC5)CC3)=C2C(C=C(OCCCN4CCCCC4)C(OC)=C2)=N1
InChiKey OUKWLRHRXOPODD-UHFFFAOYSA-N

References for UNC 0646

References are publications that support the biological activity of the product

  • G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.

    Bittencourt D et al (2012) Proc Natl Acad Sci U S A 109(48) : 19673-8.
    Read more (PubMedID: 23151507)

  • Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

    Liu F et al (2011) J Med Chem 54(17) : 6139-50.
    Read more (PubMedID: 21780790)

2 Item(s)

Grouped product items
Order: HB1423
Pack PriceQty
10mg
$217
50mg
$854
Potent, selective G9a / GLP HMTase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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