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Biological Data Biological description Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).
Solubility & Handling Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H -1,4-diazepin-1-yl)-6-methoxy-N - (1-methyl-4-piperidinyl)-4-quinazolinamine
Chemical structure
Molecular Formula C26 H43 N7 O2
PubChem identifier 44251522
SMILES CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1
InChiKey XIVUGRBSBIXXJE-UHFFFAOYSA-N
References for UNC 0224 References are publications that support the biological activity of the product
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Liu F et al (2010) J Med Chem 53(15) : 5844-57. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. Liu F et al (2009) J Med Chem 52(24) : 7950-3.
Potent, selective G9a HMTase inhibitor
![UNC 0224 [1197196-48-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1420.png "UNC 0224 [1197196-48-7]")
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