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Biological Data
| Biological description | Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine |
| Chemical structure | ![UNC 0224 [1197196-48-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "UNC 0224 [1197196-48-7]") |
| Molecular Formula | C26H43N7O2 |
| PubChem identifier | 44251522 |
| SMILES | CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1 |
| InChiKey | XIVUGRBSBIXXJE-UHFFFAOYSA-N |
References for UNC 0224
References are publications that support the biological activity of the product
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Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu F et al (2010) J Med Chem 53(15) : 5844-57. -
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Liu F et al (2009) J Med Chem 52(24) : 7950-3.
Potent, selective G9a HMTase inhibitor
![UNC 0224 [1197196-48-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1420.png "UNC 0224 [1197196-48-7]")
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