Product overview

Name UNC 0224
Alternative names Compound 8
Purity >98%
Description Potent, selective G9a HMTase inhibitor
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Biological Data

Biological description Potent and selective G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 = 15 nM).

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 7-[3-(Dimethylamino)propoxy]-2-(hex ahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N- (1-methyl-4-piperidinyl)-4-quinazolinamine
Molecular Weight 485.67
Chemical structure UNC 0224  [1197196-48-7] Chemical Structure
Molecular Formula C26H43N7O2
CAS Number 1197196-48-7
PubChem identifier 44251522
SMILES CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1
InChiKey XIVUGRBSBIXXJE-UHFFFAOYSA-N

References for UNC 0224

References are publications that support the biological activity of the product
  • Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

    Liu F et al (2010) J Med Chem 53(15) : 5844-57.
  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Liu F et al (2009) J Med Chem 52(24) : 7950-3.

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