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TX-1123

(HB0622)
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Product overview

Name TX-1123
Description Tyrosine kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Tyrosine kinase inhibitor. Inhibits Src, eEF2-K, and PKA (IC50 values are 2.2, 3.2 and 9.6 mM respectively). Shows anti-tumor actions and acts as an antiangiogenic hypoxic cell radiosensitizer.

Solubility & Handling

Solubility overview Soluble in DMSO (10mg/ml)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
Molecular Weight 312.4
Chemical structure TX-1123 [157397-06-3] Chemical Structure
Molecular Formula C20H24O3
CAS Number 157397-06-3

References for TX-1123

References are publications that support the biological activity of the product

  • Chemical properties and biological activities of cyclopentenediones: a review.

    Sevcíková Z et al (2014) Mini Rev Med Chem 14(4) : 322-31.
    Read more (PubMedID: 24605879)

  • Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione.

    Hori H et al (2004) Biochim Biophys Acta 1697(1-2) : 29-38.
    Read more (PubMedID: 15023348)

  • TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.

    Hori H et al (2002) Bioorg Med Chem 10(10) : 3257-65.
    Read more (PubMedID: 12150871)

3 Item(s)

Grouped product items
Order: HB0622
Pack PriceQty
50mg
$697
Tyrosine kinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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