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TX-1123

(HB0622)
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Product overview

Name TX-1123
Description Tyrosine kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Tyrosine kinase inhibitor. Inhibits Src, eEF2-K, and PKA (IC50 values are 2.2, 3.2 and 9.6 mM respectively). Shows anti-tumor actions and acts as an antiangiogenic hypoxic cell radiosensitizer.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
Molecular Weight 312.4
Chemical structure TX-1123 [157397-06-3] Chemical Structure
Molecular Formula C20H24O3
CAS Number 157397-06-3

References for TX-1123

References are publications that support the biological activity of the product

  • Chemical properties and biological activities of cyclopentenediones: a review.

    Sevcíková Z et al (2014) Mini Rev Med Chem 14(4) : 322-31.
    Read more (PubMedID: 24605879)

  • Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione.

    Hori H et al (2004) Biochim Biophys Acta 1697(1-2) : 29-38.
    Read more (PubMedID: 15023348)

  • TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.

    Hori H et al (2002) Bioorg Med Chem 10(10) : 3257-65.
    Read more (PubMedID: 12150871)

3 Item(s)

Grouped product items
Order: HB0622
Pack PriceQty
50mg
$677
Tyrosine kinase inhibitor
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Hazardous: $35

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