Product overview

Name Torcetrapib
Purity >99%
Description Cholesteryl ester transfer protein inhibitor
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Biological Data

Biological description Cholesteryl ester transfer protein (CETP) inhibitor. Raises HDL in dyslipidemia, improves glucose homeostasis and insulin resistance. Inhibits vasodilation and increases aldosterone to show hypertensive actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6- (trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
Molecular Weight 600.47
Chemical structure Torcetrapib  [262352-17-0] Chemical Structure
Molecular Formula C26H25F9N2O4
CAS Number 262352-17-0
PubChem identifier 159325
SMILES CC[C@H]2N(C(OCC)=O)C1=CC=C(C(F)(F)F)C=C1[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C2

References for Torcetrapib

References are publications that support the biological activity of the product
  • Raising HDL with CETP inhibitor torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters.

    Briand F et al (2014) Atherosclerosis 233(2) : 359-62.
  • Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.

    Briand F et al (2013) Arterioscler Thromb Vasc Biol 33(1) : 13-23.
  • Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.

    Connelly MA et al (2010) J Cardiovasc Pharmacol 55(5) : 459-68.

3 Item(s)