Product overview

Name TAK 715
Description Potent, p-38 MAP kinase inhibitor. Wnt/β-catenin signaling inhibitor.
Purity >99%
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Biological Data

Biological description Potent p-38 MAP kinase inhibitor (IC50 = 7.1 nM for p-38MAPKα). Also Wnt-3a-stimulated β-catenin signalling inhibitor. Shows anti-rheumatic and anti-inflammatory properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Molecular Weight 399.51
Chemical structure TAK 715  [303162-79-0] Chemical Structure
Molecular Formula C24H21N3OS
CAS Number 303162-79-0
PubChem identifier 9952773
SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
InChiKey BRYAJHADJWBFQY-UHFFFAOYSA-N

References for TAK 715

References are publications that support the biological activity of the product
  • X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.

    Azevedo R et al (2012) Acta Crystallogr D Biol Crystallogr 68(Pt 8) : 1041-50.
  • Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε.

    Verkaar F et al (2011) Chem Biol 18(4) : 485-94.
  • Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

    Miwatashi S et al (2005) J Med Chem 48(19) : 5966-79.