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Biological Data Biological description Potent p-38 MAP kinase inhibitor (IC50 = 7.1 nM for p-38MAPKα). Also Wnt-3a-stimulated β-catenin signalling inhibitor. Shows anti-rheumatic and anti-inflammatory properties.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Chemical structure
Molecular Formula C24 H21 N3 OS
PubChem identifier 9952773
SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
InChiKey BRYAJHADJWBFQY-UHFFFAOYSA-N
References for TAK 715 References are publications that support the biological activity of the product
X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors. Azevedo R et al (2012) Acta Crystallogr D Biol Crystallogr 68(Pt 8) : 1041-50. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Verkaar F et al (2011) Chem Biol 18(4) : 485-94. Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. Miwatashi S et al (2005) J Med Chem 48(19) : 5966-79.
Potent, p-38 MAP kinase inhibitor. Wnt/β-catenin signaling inhibitor.
![TAK 715 [303162-79-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0599.png "TAK 715 [303162-79-0]")
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