Product overview
| Name | TAK 715 |
| Description | Potent, p-38 MAP kinase inhibitor. Wnt/β-catenin signaling inhibitor. |
| Purity | >99% |
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Biological Data
| Biological description | Potent p-38 MAP kinase inhibitor (IC50 = 7.1 nM for p-38MAPKα). Also Wnt-3a-stimulated β-catenin signalling inhibitor. Shows anti-rheumatic and anti-inflammatory properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide |
| Molecular Weight | 399.51 |
| Chemical structure | ![TAK 715 [303162-79-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0599.png "TAK 715 [303162-79-0]") |
| Molecular Formula | C24H21N3OS |
| CAS Number | 303162-79-0 |
| PubChem identifier | 9952773 |
| SMILES | CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C |
| InChiKey | BRYAJHADJWBFQY-UHFFFAOYSA-N |
References for TAK 715
References are publications that support the biological activity of the product
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X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
Azevedo R et al (2012) Acta Crystallogr D Biol Crystallogr 68(Pt 8) : 1041-50. -
Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε.
Verkaar F et al (2011) Chem Biol 18(4) : 485-94. -
Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.
Miwatashi S et al (2005) J Med Chem 48(19) : 5966-79.
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