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SL 0101-1

(HB0584)
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Product overview

Name SL 0101-1
Alternative names SL0101
Purity >95%
Description Selective p90 ribosomal S6 kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective p90 ribosomal S6 kinase (RSK) inhibitor (IC50 = 89 nM for RSK2). Shows anti-proliferative actions against cancer cell lines.

Solubility & Handling

Solubility overview Soluble in ethanol (20mM) or DMSO (10mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H -1benzopyran-4-one
Molecular Weight 516.46
Chemical structure SL 0101-1 [77307-50-7] Chemical Structure
Molecular Formula C25H24O12
CAS Number 77307-50-7
PubChem identifier 14825856
SMILES O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2
InChiKey SXOZSDJHGMAEGZ-UHFFFAOYSA-N

References for SL 0101-1

References are publications that support the biological activity of the product

  • Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer.

    Shiota M et al (2014) Prostate 74(9) : 959-69.
    Read more (PubMedID: 24740858)

  • The selectivity of protein kinase inhibitors: a further update.

    Bain J et al (2007) Biochem J 408(3) : 297-315.
    Read more (PubMedID: 17850214)

  • Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.

    Smith JA et al (2005) Cancer Res 65(3) : 1027-34.
    Read more (PubMedID: 15705904)

3 Item(s)

Grouped product items
Order: HB0584
Pack PriceQty
500μg
$235
1mg
$344
5mg
$1,416
Selective p90 ribosomal S6 kinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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