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Biological Data
| Biological description | Selective p90 ribosomal S6 kinase (RSK) inhibitor (IC50 = 89 nM for RSK2). Shows anti-proliferative actions against cancer cell lines. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in ethanol (20mM) or DMSO (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H -1benzopyran-4-one |
| Chemical structure | ![SL 0101-1 [77307-50-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SL 0101-1 [77307-50-7]") |
| Molecular Formula | C25H24O12 |
| PubChem identifier | 14825856 |
| SMILES | O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2 |
| InChiKey | SXOZSDJHGMAEGZ-UHFFFAOYSA-N |
References for SL 0101-1
References are publications that support the biological activity of the product
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Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer.
Shiota M et al (2014) Prostate 74(9) : 959-69. -
The selectivity of protein kinase inhibitors: a further update.
Bain J et al (2007) Biochem J 408(3) : 297-315. -
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
Smith JA et al (2005) Cancer Res 65(3) : 1027-34.
Selective p90 ribosomal S6 kinase inhibitor
![SL 0101-1 [77307-50-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0584.png "SL 0101-1 [77307-50-7]")
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