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SKA 31

(HB1050)
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Product overview

Name SKA 31
Purity >99%
Description KCa3.1 channel / KCa2 channel subfamily activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Images

SKA 31 product vial image | Hello Bio
SKA 31 product vial image | Hello Bio

SKA 31 product vial image | Hello Bio

SKA 31 product vial image | Hello Bio

Biological Data

Biological description KCa3.1 channel (EC50 = 260 nM) and KCa2 subfamily activator (EC50 values are 2.9, 1.9 and 2.9 µM for KCa2.1 KCa2.2 and KCa2.3 channels respectively). Displays vasodilation and antihypertensive properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name Naphtho[1,2-d]thiazol-2-ylamine
Molecular Weight 200.26
Chemical structure SKA 31 [40172-65-4] Chemical Structure
Molecular Formula C11H8N2S
CAS Number 40172-65-4
PubChem identifier 94880
SMILES NC3=NC2=C(S3)C=CC1=CC=CC=C12
InChiKey FECQXVPRUCCUIL-UHFFFAOYSA-N

References for SKA 31

References are publications that support the biological activity of the product

  • SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts.

    Mishra RC et al (2013) Cardiovasc Res 97(2) : 339-48.
    Read more (PubMedID: 23118129)

  • Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.

    Radtke J et al (2013) Br J Pharmacol 170(2) : 293-303.
    Read more (PubMedID: 23734697)

  • Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.

    Sankaranarayanan A et al (2009) Mol Pharmacol 75(2) : 281-95.
    Read more (PubMedID: 18955585)

3 Item(s)

Grouped product items
Order: HB1050
Pack PriceQty
10mg
$111
50mg
$446
KCa3.1 channel / KCa2 channel subfamily activator
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Hazardous: $35

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