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Sipatrigine

(HB1032)
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Product overview

Name Sipatrigine
Alternative names 619C89
Purity >98%
Description Na+ / Ca+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Na+, Ca+ channel blocker (IC50 = 10 µM for R type Ca2+ channel currents). Also acts as TREK-1 antagonist and inhibits glutamate release. Analog of lamotrigine. Displays neuroprotective and antidepressant properties.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Molecular Weight 372.68
Chemical structure Sipatrigine [130800-90-7] Chemical Structure
Molecular Formula C15H16Cl3N5
CAS Number 130800-90-7
PubChem identifier 60803
SMILES ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1
InChi InChI=1S/C15H16Cl3N5/c1-22-2-4-23(5-3-22)15-20-8-11(14(19)21-15)10-6-9(16)7-12(17)13(10)18/h6-8H,2-5H2,1H3,(H2,19,20,21)
InChiKey PDOCBJADCWMDGL-UHFFFAOYSA-N
MDL number MFCD00867772

References for Sipatrigine

References are publications that support the biological activity of the product

  • Sipatrigine could have therapeutic potential for major depression and bipolar depression through antagonism of the two-pore-domain K+ channel TREK-1.

    Tsai SJ (2008) Med Hypotheses 70(3) : 548-50.
    Read more (PubMedID: 17703894)

  • The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential.

    Gao Z et al (2005) Clin Exp Pharmacol Physiol 32(12) : 1088-96.
    Read more (PubMedID: 16445575)

  • Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents.

    Hainsworth AH et al (2003) Eur J Pharmacol 467(1-3) : 77-80.
    Read more (PubMedID: 12706458)

  • BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

    Leach MJ et al (1993) Stroke 24(7) : 1063-7.
    Read more (PubMedID: 8100654)

4 Item(s)

Grouped product items
Order: HB1032
Pack PriceQty
5mg
$132
10mg
$236
25mg
$526
Na+ / Ca+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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