Product overview

Name Sephin1
Alternative names NSC65390
Purity >95%
Description Selective PP1R15A inhibitor
Write Your Own Review
You're reviewing:Sephin1
Rate this item:

Biological Data

Biological description Selective inhibitor of the stress-induced Protein Phosphatase 1 Regulatory Subunit 15A (PP1R15A). Guanabenz derivative. Does not bind the related PP1R15B. Protects cells from protein misfolding stress and prevents protein-misfolding diseases such as Charcot-Marie-Tooth 1B and amyotrophic lateral sclerosis in vivo.

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Chemical name (E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide
Molecular Weight 196.64
Chemical structure Sephin 1 [951441-04-6] Chemical Structure
Molecular Formula C8H9ClN4
CAS Number 951441-04-6
PubChem identifier 9561611
SMILES C1=CC=C(C(=C1)/C=N/N=C(N)N)Cl
InChi InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
InChiKey PDWJALXSRRSUHR-LFYBBSHMSA-N
MDL number MFCD00790608

References for Sephin1

References are publications that support the biological activity of the product
  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42

1 Item