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SCH 28080

(HB1124)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name SCH 28080
Purity >99%
Description Potent, competitive gastric K+ / H+ -ATPase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (3) Frequently bought together
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SCH 28080: Scientist Approved
SCH 28080: Scientist Approved

SCH 28080: Scientist Approved

SCH 28080: Scientist Approved

Biological Data

Biological description Potent and competitive gastric K+ / H+ -ATPase inhibitor (IC50 = 20 nM). Competes against K+ for the K+ recognition site. Able to distinguish different types of ATPases. Displays antiulcer, antisecretory and cytoprotective properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (10mM) or DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Molecular Weight 277.33
Chemical structure SCH 28080 [76081-98-6] Chemical Structure
Molecular Formula C17H15N3O
CAS Number 76081-98-6
PubChem identifier 108137
SMILES CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1
InChiKey PYKJFEPAUKAXNN-UHFFFAOYSA-N

References for SCH 28080

References are publications that support the biological activity of the product

  • SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.

    Vagin O et al (2002) Biochemistry 41(42) : 12755-62.
    Read more (PubMedID: 12379118)

  • Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080.

    Scott CK et al (1987) Biochem Pharmacol 36(1) : 97-104.
    Read more (PubMedID: 3026407)

  • Gastric antisecretory and cytoprotective activities of SCH 28080.

    Long JF et al (1983) J Pharmacol Exp Ther 226(1) : 114-20.
    Read more (PubMedID: 6864535)

3 Item(s)

Publications
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These publications cite the use of SCH 28080 purchased from Hello Bio:

  • Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

    Montalbano et al (2015) PLoS One 10(10) : e0140369
    PubMedID: 26460748

1 Item

Grouped product items
Order: HB1124
Pack PriceQty
10mg
$153
50mg
$591
Potent, competitive gastric K+ / H+ -ATPase inhibitor
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