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SB 269970 hydrochloride

(HB1684)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name SB 269970 hydrochloride
Alternative names SB-269970,SB269970
Purity >98%
Description Potent, selective 5-HT7 receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (4) Frequently bought together
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Biological Data

Biological description Potent and selective 5-HT7 receptor antagonist. Selective for for 5-HT7A over 5-HT5A and 5-HT1B (pKi values are 8.9, 7.2 and 6.0 respectively). Inhibits hyperactivity induced by amphetamine and ketamine. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
Molecular Weight 388.95
Chemical structure SB 269970 hydrochloride [261901-57-9] Chemical Structure
Molecular Formula C18H28N2O3S.HCl
CAS Number 261901-57-9
PubChem identifier 11957684
SMILES OC1=CC(S(N2[C@@H](CCN3CCC(C)CC3)CCC2)(=O)=O)=CC=C1.Cl
InChiKey XQCJOYZLWFNDIO-PKLMIRHRSA-N

References for SB 269970 hydrochloride

References are publications that support the biological activity of the product

  • Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats.

    Nikiforuk A et al (2013) PLoS One 8(6) : e66695.
    Read more (PubMedID: 23776692)

  • Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity.

    Galici R et al (2008) Behav Pharmacol 19(2) : 153-9.
    Read more (PubMedID: 18332680)

  • Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.

    Hagan JJ et al (2000) Br J Pharmacol 130(3) : 539-48.
    Read more (PubMedID: 10821781)

  • A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

    Lovell PJ et al (2000) J Med Chem 43(3) : 342-5.
    Read more (PubMedID: 10669560)

4 Item(s)

Publications
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These publications cite the use of SB 269970 hydrochloride purchased from Hello Bio:

  • Activation of 5-HT(7) receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse.

    Siwiec M et al (2024) Pharmacological reports : PR 76 : 1377-1389
    PubMedID: 39487932

1 Item

Grouped product items
Order: HB1684
Pack PriceQty
10mg
$218
50mg
$846
Potent, selective 5-HT7 receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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