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Biological Data Biological description Potent and selective 5-HT7 receptor antagonist. Selective for for 5-HT7A over 5-HT5A and 5-HT1B (pKi values are 8.9, 7.2 and 6.0 respectively). Inhibits hyperactivity induced by amphetamine and ketamine. Blood-brain barrier permeable.
Solubility & Handling Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2R )-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
Chemical structure
Molecular Formula C18 H28 N2 O3 S.HCl
PubChem identifier 11957684
SMILES OC1=CC(S(N2[C@@H](CCN3CCC(C)CC3)CCC2)(=O)=O)=CC=C1.Cl
InChiKey XQCJOYZLWFNDIO-PKLMIRHRSA-N
References for SB 269970 hydrochloride References are publications that support the biological activity of the product
Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. Nikiforuk A et al (2013) PLoS One 8(6) : e66695. Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. Galici R et al (2008) Behav Pharmacol 19(2) : 153-9. Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Hagan JJ et al (2000) Br J Pharmacol 130(3) : 539-48. A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970). Lovell PJ et al (2000) J Med Chem 43(3) : 342-5.
Potent, selective 5-HT7 receptor antagonist
![SB 269970 hydrochloride [261901-57-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1684.png "SB 269970 hydrochloride [261901-57-9]")
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