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Biological Data
| Biological description | Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Inhibits protein phosphatase 1 (PP1) action on elF2α without inhibiting dephosphorylation of other PP1 substrates. Inhibit herpes simplex virus replication and protects cells from apoptosis through endoplasmic reticulum stress. Shows potential neuroprotective actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propen amide |
| Chemical structure | ![Salubrinal [405060-95-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Salubrinal [405060-95-9]") |
| Molecular Formula | C21H17N4OSCl3 |
| PubChem identifier | 5717801 |
| SMILES | S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1 |
| InChiKey | LCOIAYJMPKXARU-VAWYXSNFSA-N |
References for Salubrinal
References are publications that support the biological activity of the product
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Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.
Cai XH et al (2014) Exp Neurol 257 : 148-56. -
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.
Boyce M et al (2008) Cell Death Differ 15(3) : 589-99. -
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Boyce M et al (2005) Science 307(5711) : 935-9.
Selective elF2α dephosphorylation inhibitor
![Salubrinal [405060-95-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0573.png "Salubrinal [405060-95-9]")
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