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Salubrinal

(HB0573)
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Product overview

Name Salubrinal
Alternative names eIF-2α Inhibitor
Purity >99%
Description Selective elF2α dephosphorylation inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Inhibits protein phosphatase 1 (PP1) action on elF2α without inhibiting dephosphorylation of other PP1 substrates. Inhibit herpes simplex virus replication and protects cells from apoptosis through endoplasmic reticulum stress. Shows potential neuroprotective actions.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propen amide
Molecular Weight 479.81
Chemical structure Salubrinal [405060-95-9] Chemical Structure
Molecular Formula C21H17N4OSCl3
CAS Number 405060-95-9
PubChem identifier 5717801
SMILES S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1
InChiKey LCOIAYJMPKXARU-VAWYXSNFSA-N

References for Salubrinal

References are publications that support the biological activity of the product

  • Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.

    Cai XH et al (2014) Exp Neurol 257 : 148-56.
    Read more (PubMedID: 24810321)

  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.

    Boyce M et al (2008) Cell Death Differ 15(3) : 589-99.
    Read more (PubMedID: 18188169)

  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

    Boyce M et al (2005) Science 307(5711) : 935-9.
    Read more (PubMedID: 15705855)

3 Item(s)

Grouped product items
Order: HB0573
Pack PriceQty
5mg
$121
10mg
$182
25mg
$389
Selective elF2α dephosphorylation inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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