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Rottlerin

(HB0561)
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Product overview

Name Rottlerin
Description PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Protein kinase C inhibitor (IC50 = 3-6 µM for PKC-δ). Inhibits cAM-kinase III, PRAK (IC50 = 1.9 µM) and MAPKAP-K2 (IC50 = 5.4 µM). Novel lipoprotein receptor-related protein-6 (LRP6) inhibitor. Also suppresses Wnt/β-catenin and mTORC1 signalling. Displays cell growth suppressing, apoptosis inducing and anti-angiogenesis properties.

Solubility & Handling

Solubility overview Soluble in ethanol (2mM, gentle warming) or DMSO (20mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Molecular Weight 516.55
Chemical structure Rottlerin [82-08-6] Chemical Structure
Molecular Formula C30H28O8
CAS Number 82-08-6
PubChem identifier 5281847
SMILES CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O
InChiKey DEZFNHCVIZBHBI-ZHACJKMWSA-N

References for Rottlerin

References are publications that support the biological activity of the product

  • Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.

    Lu W et al (2014) Cell Signal 26(6) : 1303-9.
    Read more (PubMedID: 24607787)

  • Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.

    Lu QY et al (2013) J Chromatogr Sep Tech 4(1) :
    Read more (PubMedID: 24482742)

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    Read more (PubMedID: 10998351)

  • Rottlerin, a novel protein kinase inhibitor.

    Gschwendt M et al (1994) Biochem Biophys Res Commun 199(1) : 93-8.
    Read more (PubMedID: 8123051)

4 Item(s)

Grouped product items
Order: HB0561
Pack PriceQty
50mg
$393
PKC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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