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Biological Data
| Biological description | Protein kinase C inhibitor (IC50 = 3-6 µM for PKC-δ). Inhibits cAM-kinase III, PRAK (IC50 = 1.9 µM) and MAPKAP-K2 (IC50 = 5.4 µM). Novel lipoprotein receptor-related protein-6 (LRP6) inhibitor. Also suppresses Wnt/β-catenin and mTORC1 signalling. Displays cell growth suppressing, apoptosis inducing and anti-angiogenesis properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in ethanol (2mM, gentle warming) or DMSO (20mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone |
| Chemical structure | ![Rottlerin [82-08-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Rottlerin [82-08-6]") |
| Molecular Formula | C30H28O8 |
| PubChem identifier | 5281847 |
| SMILES | CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O |
| InChiKey | DEZFNHCVIZBHBI-ZHACJKMWSA-N |
References for Rottlerin
References are publications that support the biological activity of the product
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Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.
Lu W et al (2014) Cell Signal 26(6) : 1303-9. -
Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.
Lu QY et al (2013) J Chromatogr Sep Tech 4(1) : -
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105. -
Rottlerin, a novel protein kinase inhibitor.
Gschwendt M et al (1994) Biochem Biophys Res Commun 199(1) : 93-8.
![Rottlerin [82-08-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0561.png "Rottlerin [82-08-6]")
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