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Biological Data Biological description Potent SUR1 / Kir 6.2 channel blocker (KD = 0.42 nM). Also binds to sulphonylurea receptor 1 (SUR1) alone (KD = 59 nM). Displays antidiabetic properties.
Solubility & Handling Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 2-Ethoxy-4-[2-[[(1S )-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benz oic acid
Chemical structure
Molecular Formula C27 H36 N2 O4
SMILES O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2
InChiKey FAEKWTJYAYMJKF-QHCPKHFHSA-N
References for Repaglinide References are publications that support the biological activity of the product
Novel anti-inflammatory effects of repaglinide in rodent models of inflammation. Tung D et al (2011) Pharmacology 88(5-6) : 295-301. Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels. Hansen AM et al (2005) Br J Pharmacol 144(4) : 551-7. Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals. Gumieniczek A et al (2005) Pharmacol Res 52(2) : 162-6.
Potent SUR1 / Kir 6.2 channel blocker
![Repaglinide [135062-02-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1106.png "Repaglinide [135062-02-1]")
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