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Raloxifene hydrochloride

(HB2509)
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Product overview

Name Raloxifene hydrochloride
Alternative names LY 139481, Keoxifene
Purity >98%
Description Selective estrogen receptor modulator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective estrogen receptor modulator (Ki values are 0.38 and 5.6 nM at Erα and Erβ respectively). Shows estrogenic activity in bone and anti-estrogenic activity in breast tissue. Also shows antitumor and autophagy inducing effects. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name [6-Hydroxy-2-(4-hydroxyphenyl)benzo [b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride
Molecular Weight 510.04
Chemical structure Raloxifene hydrochloride Chemical Structure
Molecular Formula C28H27NO4S.HCl
CAS Number 82640-04-8
PubChem identifier 54900
SMILES Cl.OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=CC=C(O)C=C2S1
InChiKey BKXVVCILCIUCLG-UHFFFAOYSA-N

References for Raloxifene hydrochloride

References are publications that support the biological activity of the product

  • Raloxifene Induces Autophagy-Dependent Cell Death in Breast Cancer Cells via the Activation of AMP-Activated Protein Kinase.

    Kim DE et al (2015) Mol Cells 38(2) : 138-44.
    Read more (PubMedID: 25537862)

  • Antagonists selective for estrogen receptor alpha.

    Sun J et al (2002) Endocrinology 143(3) : 941-7.
    Read more (PubMedID: 11861516)

  • Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulation.

    Bryant HU (2001) Rev Endocr Metab Disord 2(1) : 129-38.
    Read more (PubMedID: 11704975)

3 Item(s)

Grouped product items
Order: HB2509
Pack PriceQty
50mg
$114
Selective estrogen receptor modulator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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