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Biological Data

Biological description Protein tyrosine phosphatase (PTP) inhibitor. Attenuates oligodendrocyte maturation. Impairs the differentiation of endothelial cells. Shows anti-angiogenic actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10mg/ml) or ACN.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-methanesulfonamide
Molecular Weight 608.6
Molecular Formula C26H26F6N2O4S2
CAS Number 329317-98-8
PubChem identifier 6420094
SMILES CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)NS(=O)(=O)C(F)(F)F
InChi InChI=1S/C26H26F6N2O4S2/c1-23(2,19-9-13-21(14-10-19)33-39(35,36)25(27,28)29)17-5-7-18(8-6-17)24(3,4)20-11-15-22(16-12-20)34-40(37,38)26(30,31)32/h5-16,33-34H,1-4H3
InChiKey JWNAVYMNAQDLHX-UHFFFAOYSA-N

References for PTP Inhibitor IV

References are publications that support the biological activity of the product
  • SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro.

    Liu X et al (2011) PLoS One 6(6) : e21058.
  • Phosphatase inhibitors with anti-angiogenic effect in vitro.

    Sylvest L et al (2010) APMIS 118(1) : 49-59.
  • PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14).

    Park JE et al (2009) Biochem Biophys Res Commun 387(4) : 795-9.