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Biological Data
| Biological description | Protein tyrosine phosphatase (PTP) inhibitor. Attenuates oligodendrocyte maturation. Impairs the differentiation of endothelial cells. Shows anti-angiogenic actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (10mg/ml) or ACN. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-methanesulfonamide |
| Molecular Formula | C26H26F6N2O4S2 |
| PubChem identifier | 6420094 |
| SMILES | CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)NS(=O)(=O)C(F)(F)F |
| InChi | InChI=1S/C26H26F6N2O4S2/c1-23(2,19-9-13-21(14-10-19)33-39(35,36)25(27,28)29)17-5-7-18(8-6-17)24(3,4)20-11-15-22(16-12-20)34-40(37,38)26(30,31)32/h5-16,33-34H,1-4H3 |
| InChiKey | JWNAVYMNAQDLHX-UHFFFAOYSA-N |
References for PTP Inhibitor IV
References are publications that support the biological activity of the product
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SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro.
Liu X et al (2011) PLoS One 6(6) : e21058. -
Phosphatase inhibitors with anti-angiogenic effect in vitro.
Sylvest L et al (2010) APMIS 118(1) : 49-59. -
PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14).
Park JE et al (2009) Biochem Biophys Res Commun 387(4) : 795-9.
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