Potent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in DMSO (10mM) or ethanol (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.
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