Potent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (10mM) or ethanol (10mM)
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.
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