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Biological Data

Biological description Potent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (10mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight 281.36
Molecular Formula C16H19N5
CAS Number 172889-26-8
PubChem identifier 1400
SMILES CC1=CC=C(C=C1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)C
InChiKey ZVPDNRVYHLRXLX-UHFFFAOYSA-N

References for PP 1

References are publications that support the biological activity of the product
  • The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.

    Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.
  • The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.

    Tatton L et al (2003) J Biol Chem 278(7) : 4847-53.
  • Structural basis for selective inhibition of Src family kinases by PP1.

    Liu Y et al (1999) Chem Biol 6(9) : 671-8.
  • Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

    Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.