Product overview

Name Phloretin
Purity >98%
Description PKC inhibitor
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Biological Data

Biological description Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist (IC50 = 16 µM). Inhibits GLUT2 glucose transport. Shows apoptotic, antitumor, antioxidant and immunomodulatory actions.

Solubility & Handling

Solubility overview Soluble in ethanol or methanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 274.26
Chemical structure Phloretin  [60-82-2] Chemical Structure
Molecular Formula C15H14O5
CAS Number 60-82-2
PubChem identifier 4788
SMILES OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1

References for Phloretin

References are publications that support the biological activity of the product
  • Immunomodulation of phloretin by impairing dendritic cell activation and function.

    Lin CC et al (2014) Food Funct 5(5) : 997-1006.
  • In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter.

    Wu CH et al (2009) Int J Cancer 124(9) : 2210-9.
  • Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells.

    Kobori M et al (1999) Biosci Biotechnol Biochem 63(4) : 719-25.
  • Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes.

    Kitanaka J et al (1993) J Neurochem 60(2) : 704-8.

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