Potent and selective acid pump antagonist (pIC50 values are 6.03, 6.04 and 6.01 for Porcine, Canine and Human recombinant ion leaky assay respectively). Competitively inhibits H+, K+ -ATPase but exhibits no activity against Na+, K+ -ATPase. Displays greater potency in acidic conditions. Also inhibits gastric acid secretion in dogs.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.
Mori H et al (2009) J Pharmacol Exp Ther 328(2) : 671-9.
![PF 3716556 [928774-43-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1123.png "PF 3716556 [928774-43-0]")
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