Product overview

Name PF 03814735
Purity >98%
Description Potent Aurora kinase inhibitor
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Biological Data

Biological description Potent Aurora kinase inhibitor. Reversibly inhibits Aurora B and -A (IC50 values are 0.8 and 5 nM respectively). Shows antiproliferative and anti-cancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM) or ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name N-[2-[(1S,4R)-6-[[4-(Cyclobutylamin o)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3, 4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]- acetamide
Molecular Weight 474.48
Chemical structure PF 03814735  [942487-16-3] Chemical Structure
Molecular Formula C23H25F3N6O2
CAS Number 942487-16-3
PubChem identifier 51346455
SMILES [H][C@@]3(N5C(CNC(C)=O)=O)CC[C@@]5([H])C(C3=C4)=CC=C4NC1=NC(NC2CCC2)=C(C(F)(F)F)C=N1

References for PF 03814735

References are publications that support the biological activity of the product
  • An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.

    Hook KE et al (2012) Mol Cancer Ther 11(3) : 710-9.
  • PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.

    Jani JP et al (2010) Mol Cancer Ther 9(4) : 883-94.

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