Product overview

Name Pepstatin A
Purity >98%
Description Aspartic protease inhibitor
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Biological Data

Biological description Aspartic protease inhibitor. Widely used as a research tool in studies of protease mechanisms and biological functions. Inhibits degradation of autophagic cargo inside autophagolysosomes.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 685.9
Chemical structure Pepstatin A [26305-03-3] Chemical Structure
Molecular Formula C34H63N5O9
CAS Number 26305-03-3
PubChem identifier 5478883
SMILES O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O
InChiKey FAXGPCHRFPCXOO-LXTPJMTPSA-N
Appearance White to off-white powder

References for Pepstatin A

References are publications that support the biological activity of the product
  • Pepstatin A Alters Host Cell Autophagic Machinery and Leads to a Decrease in Influenza A Virus Production

    Matarrese et al (2011) J Cell Physiol 226(12) : 3368-77
  • Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-induced Osteoclast Differentiation

    Yoshida et al (2006) J Biochem 139(3) : 583-90
  • Pepstatin, a New Pepsin Inhibitor Produced by Actinomycetes

    Umezawa et al (1970) J Antibiot (Tokyo) 23(5) : 259-62

3 Item(s)