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Biological Data Biological description Aspartic protease inhibitor. Widely used as a research tool in studies of protease mechanisms and biological functions. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Solubility & Handling Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical structure
Molecular Formula C34 H63 N5 O9
PubChem identifier 5478883
SMILES O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O
InChiKey FAXGPCHRFPCXOO-LXTPJMTPSA-N
Appearance White to off-white powder
References for Pepstatin A References are publications that support the biological activity of the product
Pepstatin A Alters Host Cell Autophagic Machinery and Leads to a Decrease in Influenza A Virus Production Matarrese et al (2011) J Cell Physiol 226(12) : 3368-77 Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-induced Osteoclast Differentiation Yoshida et al (2006) J Biochem 139(3) : 583-90 Pepstatin, a New Pepsin Inhibitor Produced by Actinomycetes Umezawa et al (1970) J Antibiot (Tokyo) 23(5) : 259-62
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Aspartic protease inhibitor