Broad spectrum protein kinase C (PKC) agonist. Also inhibits AKT pathway. Displays pro-apoptotic, anti-proliferative, pro-inflammatory and anti-cancer properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (2mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).
Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.
Serova M et al (2008) Mol Cancer Ther 7(4) : 915-22.
Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
Benhadji KA et al (2008) Br J Cancer 99(11) : 1808-15.
![PEP 005 [75567-37-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0482.png "PEP 005 [75567-37-2]")
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