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Penitrem A

(HB1057)
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Product overview

Name Penitrem A
Purity >98%
Description Potent, selective KCa1.1 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective KCa1.1 channel blocker (IC50 values are 6.4 and 64.4 nM for α-subunit and β1 subunits respectively). Displays little or no activity at CaCC, Kv1.5 and KATP channels. Neurotoxin produced by Penicillium genus. Displays enhancing smooth muscle contracting and tremorgenic properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Molecular Weight 634.2
Chemical structure Penitrem A [12627-35-9] Chemical Structure
Molecular Formula C37H44ClNO6
CAS Number 12627-35-9
PubChem identifier 6610243
SMILES O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C
InChiKey JDUWHZOLEDOQSR-JKPSMKLGSA-N

References for Penitrem A

References are publications that support the biological activity of the product

  • Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

    Asano S et al (2012) J Pharmacol Exp Ther 342(2) : 453-60.
    Read more (PubMedID: 22580348)

  • Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice.

    Moldes-Anaya A et al (2012) Toxicon 60(8) : 1428-35.
    Read more (PubMedID: 23085423)

  • In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A.

    Moldes-Anaya A et al (2009) Drug Chem Toxicol 32(1) : 26-37.
    Read more (PubMedID: 19514936)

3 Item(s)

Grouped product items
Order: HB1057
Pack PriceQty
1mg
$116
5mg
$475
Potent, selective KCa1.1 channel blocker
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Hazardous: $35

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