Product overview

Name Penitrem A
Purity >98%
Description Potent, selective KCa1.1 channel blocker
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Biological Data

Biological description Potent and selective KCa1.1 channel blocker (IC50 values are 6.4 and 64.4 nM for α-subunit and β1 subunits respectively). Displays little or no activity at CaCC, Kv1.5 and KATP channels. Neurotoxin produced by Penicillium genus. Displays enhancing smooth muscle contracting and tremorgenic properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Molecular Weight 634.2
Chemical structure Penitrem A  [12627-35-9] Chemical Structure
Molecular Formula C37H44ClNO6
CAS Number 12627-35-9
PubChem identifier 6610243
SMILES O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C

References for Penitrem A

References are publications that support the biological activity of the product
  • Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

    Asano S et al (2012) J Pharmacol Exp Ther 342(2) : 453-60.
  • Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice.

    Moldes-Anaya A et al (2012) Toxicon 60(8) : 1428-35.
  • In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A.

    Moldes-Anaya A et al (2009) Drug Chem Toxicol 32(1) : 26-37.

3 Item(s)