Product overview

Name PAC 1
Purity >98%
Description Procaspase-activating compound
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Biological Data

Biological description Procaspase-activating compound. Chelates inhibitory zinc ions and activates procaspase-3 to caspase-3 (EC50 = 0.22 µM). Activates procaspase-7 (EC50 = 4.5 µM). No effect at low pH as procaspase autoactivates. Causes Ero1α-dependent calcium leakage from the endoplasmic reticulum to mitochondria. Shows apoptotic and anti-cancer actions.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Molecular Weight 392.5
Molecular Formula C23H28N4O2
CAS Number 315183-21-2
PubChem identifier 9675990
SMILES O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1
InChiKey YQNRVGJCPCNMKT-LFVJCYFKSA-N

References for PAC 1

References are publications that support the biological activity of the product
  • ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).

    Seervi M et al (2013) Cell Death Dis 4 : e968.
  • Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.

    Peterson QP et al (2009) J Med Chem 52(18) : 5721-31.
  • Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.

    Putt KS et al (2006) Nat Chem Biol 2(10) : 543-50.

3 Item(s)