Procaspase-activating compound. Chelates inhibitory zinc ions and activates procaspase-3 to caspase-3 (EC50 = 0.22 µM). Activates procaspase-7 (EC50 = 4.5 µM). No effect at low pH as procaspase autoactivates. Causes Ero1α-dependent calcium leakage from the endoplasmic reticulum to mitochondria. Shows apoptotic and anti-cancer actions.
Solubility & Handling
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).
Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.
Peterson QP et al (2009) J Med Chem 52(18) : 5721-31.
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