Product overview

Name Oncrasin 1
Description Small molecule RNA polymerase II inhibitor
Purity >98%
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Biological Data

Biological description Small molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC50 = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Molecular Weight 269.73
Chemical structure Oncrasin 1  [75629-57-1] Chemical Structure
Molecular Formula C16H12ClNO
CAS Number 75629-57-1
PubChem identifier 872445
SMILES O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12
InChiKey ZDRQMXCSSAPUMM-UHFFFAOYSA-N

References for Oncrasin 1

References are publications that support the biological activity of the product
  • Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

    Wu S et al (2011) J Med Chem 54(8) : 2668-79.
  • Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

    Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8.
  • Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

    Guo W et al (2008) Cancer Res 68(18) : 7403-8.