Oncrasin 1

Name: Oncrasin 1
SKU: HB0473
Price: 506 USD
Availability: InStock

(HB0473)

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Technical documents: Datasheet

Product overview

Name

Oncrasin 1

Purity

>98%

Description

Small molecule RNA polymerase II inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3)

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Biological Data

Biological description

Small molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC₅₀ = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in DMSO (100mM) or ethanol (25mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde

Molecular Weight

269.73

Chemical structure

Molecular Formula

C₁₆H₁₂ClNO

CAS Number

75629-57-1

PubChem identifier

872445

SMILES

O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12

InChiKey

ZDRQMXCSSAPUMM-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Oncrasin 1

References are publications that support the biological activity of the product

Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.
Wu S et al (2011) J Med Chem 54(8) : 2668-79.
Read more (PubMedID: 21443218)
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8.
Read more (PubMedID: 19208825)
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Guo W et al (2008) Cancer Res 68(18) : 7403-8.
Read more (PubMedID: 18794128)

Small molecule RNA polymerase II inhibitor

Order: HB0473
Pack	Price	Qty
50mg	$506

Oncrasin 1

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Oncrasin 1

Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

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Oncrasin 1

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Oncrasin 1

Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area