Product overview
| Name | Oncrasin 1 |
| Description | Small molecule RNA polymerase II inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Small molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC50 = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (25mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde |
| Molecular Weight | 269.73 |
| Chemical structure | ![Oncrasin 1 [75629-57-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0473.png "Oncrasin 1 [75629-57-1]") |
| Molecular Formula | C16H12ClNO |
| CAS Number | 75629-57-1 |
| PubChem identifier | 872445 |
| SMILES | O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12 |
| InChiKey | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
References for Oncrasin 1
References are publications that support the biological activity of the product
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Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.
Wu S et al (2011) J Med Chem 54(8) : 2668-79. -
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8. -
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Guo W et al (2008) Cancer Res 68(18) : 7403-8.
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