Potent and selective P/Q-type Ca2+ channel blocker (IC50 = 127 nM for Q type channels). Displays little or no activity at L-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.
Solubility & Handling
Solubility overview
Soluble in water
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons.
Kuwada M et al (1994) Mol Pharmacol 46(4) : 587-93.