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ω-Agatoxin TK

(HB1213)
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Product overview

Name ω-Agatoxin TK
Alternative names Agatoxin IVB
Description Potent, selective P-type / Q-type Ca2+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective P/Q-type Ca2+ channel blocker (IC50 = 127 nM for Q type channels). Displays little or no activity at L-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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x
More Info

Dilution

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More Info

Chemical Data

Molecular Weight 5273.02
Molecular Formula C215H337N65O70S10
CAS Number 158484-42-5
PubChem identifier 90488781
SMILES [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CC=C(O)C=C5)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC5=C1C=CC=C5)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(O)=O
InChiKey MBXCGHHUBOKUGG-UHFFFAOYSA-N

References for ω-Agatoxin TK

References are publications that support the biological activity of the product

  • High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK.

    Barral J et al (2001) Eur J Pharmacol 430(2-3) : 167-73.
    Read more (PubMedID: 11711028)

  • A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons.

    Teramoto T et al (1997) Brain Res 756(1-2) : 225-30.
    Read more (PubMedID: 9187336)

  • Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons.

    Kuwada M et al (1994) Mol Pharmacol 46(4) : 587-93.
    Read more (PubMedID: 7969037)

3 Item(s)

Grouped product items
Order: HB1213
Pack PriceQty
100μg
$1,582
Potent, selective P-type / Q-type Ca2+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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