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ω-Agatoxin TK

(HB1213)
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Product overview

Name ω-Agatoxin TK
Alternative names Agatoxin IVB
Description Potent, selective P-type / Q-type Ca2+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective P/Q-type Ca2+ channel blocker (IC50 = 127 nM for Q type channels). Displays little or no activity at L-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Molecular Weight 5273.02
Molecular Formula C215H337N65O70S10
CAS Number 158484-42-5
PubChem identifier 90488781
SMILES [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CC=C(O)C=C5)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC5=C1C=CC=C5)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(O)=O
InChiKey MBXCGHHUBOKUGG-UHFFFAOYSA-N

References for ω-Agatoxin TK

References are publications that support the biological activity of the product

  • High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK.

    Barral J et al (2001) Eur J Pharmacol 430(2-3) : 167-73.
    Read more (PubMedID: 11711028)

  • A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons.

    Teramoto T et al (1997) Brain Res 756(1-2) : 225-30.
    Read more (PubMedID: 9187336)

  • Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons.

    Kuwada M et al (1994) Mol Pharmacol 46(4) : 587-93.
    Read more (PubMedID: 7969037)

3 Item(s)

Grouped product items
Order: HB1213
Pack PriceQty
100μg
$1,536
Potent, selective P-type / Q-type Ca2+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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