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NS 309

(HB1049)
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Product overview

Name NS 309
Purity >98%
Description Potent, selective KCa3.1 / KCa2 channel subfamily activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent and selective KCa3.1 channel and KCa2 channel subfamily activator (EC50 = 0.3 µM for KCa2.3). Exhibits little or no activity at KCa1.1 channels. Displays >1000 fold higher potency than 1-EBIO.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Molecular Weight 231.04
Chemical structure NS 309 [18711-16-5] Chemical Structure
Molecular Formula C8H4Cl2N2O2
CAS Number 18711-16-5
PubChem identifier 11637204
SMILES ClC1=C2C(C(C(N2)=O)=NO)=CC=C1Cl
InChiKey CVOUSAVHMDXCKG-UHFFFAOYSA-N

References for NS 309

References are publications that support the biological activity of the product

  • NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.

    Parajuli SP et al (2013) Br J Pharmacol 168(7) : 1611-25.
    Read more (PubMedID: 23145946)

  • Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

    Hougaard C et al (2007) Br J Pharmacol 151(5) : 655-65.
    Read more (PubMedID: 17486140)

  • Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

    Strøbaek D et al (2004) Biochim Biophys Acta 1665(1-2) : 1-5.
    Read more (PubMedID: 15471565)

3 Item(s)

Grouped product items
Order: HB1049
Pack PriceQty
10mg
$87
50mg
$345
Potent, selective KCa3.1 / KCa2 channel subfamily activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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