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NS 1643

(HB1066)
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Product overview

Name NS 1643
Purity >98%
Description Kv11.1 channel activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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NS 1643 product vial image | Hello Bio
NS 1643 product vial image | Hello Bio

NS 1643 product vial image | Hello Bio

NS 1643 product vial image | Hello Bio

Biological Data

Biological description Kv11.1 channel activator (EC50 = 10.5 µM). Also activates Kv11.2 channels via different mechanism and Kv11.3 channels. A diphenylurea derivative that irreversibly inhibits cell proliferation.

Solubility & Handling

Solubility overview Soluble in ethanol (100mM) or DMSO (25mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N,N'-Bis[2-hydroxy-5-(trifluoromethy l)phenyl]urea
Molecular Weight 380.24
Chemical structure NS 1643 [448895-37-2] Chemical Structure
Molecular Formula C15H10F6N2O3
CAS Number 448895-37-2
PubChem identifier 10177784
SMILES OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1
InChiKey NJFVQMRYJZHGME-UHFFFAOYSA-N

References for NS 1643

References are publications that support the biological activity of the product

  • Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

    Lansu K et al (2013) Cell Death Dis 4 : e652.
    Read more (PubMedID: 23744352)

  • Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.

    Bilet A et al (2012) PLoS One 7(11) : e50886.
    Read more (PubMedID: 23226420)

  • Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb P et al (2007) Neuropharmacology 53(2) : 283-94.
    Read more (PubMedID: 17610913)

  • Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

    Hansen RS et al (2006) Mol Pharmacol 69(1) : 266-77.
    Read more (PubMedID: 16219910)

4 Item(s)

Grouped product items
Order: HB1066
Pack PriceQty
10mg
$136
50mg
$531
Kv11.1 channel activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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