NS 1643

Name: NS 1643
Brand: Hello Bio
SKU: HB1066
Price: 135 USD
Availability: InStock

(HB1066)

Be the first to add a publication

Technical documents: SDS Datasheet

Product overview

Name

NS 1643

Purity

>98%

Description

K_v11.1 channel activator

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

Write Your Own Review

Images

NS 1643 product vial image | Hello Bio

Biological Data

Biological description

K_v11.1 channel activator (EC₅₀ = 10.5 µM). Also activates K_v11.2 channels via different mechanism and K_v11.3 channels. A diphenylurea derivative that irreversibly inhibits cell proliferation.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in ethanol (100mM) or DMSO (25mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

N,N'-Bis[2-hydroxy-5-(trifluoromethy l)phenyl]urea

Molecular Weight

380.24

Chemical structure

Molecular Formula

C₁₅H₁₀F₆N₂O₃

CAS Number

448895-37-2

PubChem identifier

10177784

SMILES

OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1

InChiKey

NJFVQMRYJZHGME-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for NS 1643

References are publications that support the biological activity of the product

Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.
Lansu K et al (2013) Cell Death Dis 4 : e652.
Read more (PubMedID: 23744352)
Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.
Bilet A et al (2012) PLoS One 7(11) : e50886.
Read more (PubMedID: 23226420)
Activation of ERG2 potassium channels by the diphenylurea NS1643.
Elmedyb P et al (2007) Neuropharmacology 53(2) : 283-94.
Read more (PubMedID: 17610913)
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen RS et al (2006) Mol Pharmacol 69(1) : 266-77.
Read more (PubMedID: 16219910)

K_v11.1 channel activator

Order: HB1066
Pack	Price	Qty
10mg	$135
50mg	$525

NS 1643

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for NS 1643

Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.

Activation of ERG2 potassium channels by the diphenylurea NS1643.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

About you

Tell us about your publication!

Captcha

New Products in this Area

NS 1643

Product overview

Images

NS 1643 product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for NS 1643

Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.

Activation of ERG2 potassium channels by the diphenylurea NS1643.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

About you

Tell us about your publication!

Captcha

About you

How can we help you?

New Products in this Area