Product overview
| Name | NS 1619 |
| Purity | >98% |
| Description | Potent, selective KCa1.1 channel activator |
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Biological Data
| Biological description | Potent and selective KCa1.1 channel activator (EC50 = 3.6 µM). Selectively increases the blood brain barrier permeability. Displays vasorelaxant properties |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | 1,3-Dihydro-1-[2-hydroxy-5-(trifluo romethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one |
| Molecular Weight | 362.23 |
| Chemical structure | ![NS 1619 [153587-01-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1048.png "NS 1619 [153587-01-0]") |
| Molecular Formula | C15H8F6N2O2 |
| CAS Number | 153587-01-0 |
| PubChem identifier | 4552 |
| SMILES | O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O |
| InChiKey | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for NS 1619
References are publications that support the biological activity of the product
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Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
Gu YT et al (2012) J Mol Neurosci 48(1) : 302-12. -
Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.
Soder RP et al (2011) Eur J Pharmacol 670(1) : 252-9. -
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
Debska G et al (2003) Biochem Pharmacol 65(11) : 1827-34. -
5-(4'-Substituted-2'-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I.
Biagi G et al (2000) Eur J Med Chem 35(7-8) : 715-20.