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NS 1619

(HB1048)
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Product overview

Name NS 1619
Purity >98%
Description Potent, selective KCa1.1 channel activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent and selective KCa1.1 channel activator (EC50 = 3.6 µM). Selectively increases the blood brain barrier permeability. Displays vasorelaxant properties

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1,3-Dihydro-1-[2-hydroxy-5-(trifluo romethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Molecular Weight 362.23
Chemical structure NS 1619 [153587-01-0] Chemical Structure
Molecular Formula C15H8F6N2O2
CAS Number 153587-01-0
PubChem identifier 4552
SMILES O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O
InChiKey YLFMCMWKHSDUCT-UHFFFAOYSA-N

References for NS 1619

References are publications that support the biological activity of the product

  • Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.

    Gu YT et al (2012) J Mol Neurosci 48(1) : 302-12.
    Read more (PubMedID: 22581438)

  • Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.

    Soder RP et al (2011) Eur J Pharmacol 670(1) : 252-9.
    Read more (PubMedID: 21914438)

  • Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.

    Debska G et al (2003) Biochem Pharmacol 65(11) : 1827-34.
    Read more (PubMedID: 12781334)

  • 5-(4'-Substituted-2'-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I.

    Biagi G et al (2000) Eur J Med Chem 35(7-8) : 715-20.
    Read more (PubMedID: 10960187)

4 Item(s)

Grouped product items
Order: HB1048
Pack PriceQty
5mg
$105
10mg
$155
25mg
$268
Potent, selective KCa1.1 channel activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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